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Interspecific and intraspecific variation in gastrointestinal microbiota composition of parrots and its association with incidence of selected disorders
Černá, Kateřina ; Vinkler, Michal (advisor) ; Rychlík, Ivan (referee)
Captive parrots are susceptible to various digestive, metabolic, and behavioural disorders. Recent research in other vertebrates has suggested that these disorders can be linked to the gut microbiota, directly or through the microbiota-gut-brain axis. Although many commercial probiotic products intended for the use in parrots advertise beneficial effects on digestion and mental well- being, these statements are not sufficiently supported with publicly available scientific evidence, but probably rather based on the extrapolation of the knowledge of microbiota-gut-brain interactions in poultry, mice, and humans. However, there are substantial differences in the gastrointestinal tract morphology and gut microbiota composition between parrots and these model vertebrates. This thesis aimed to describe the interspecific and intraspecific variation in the gut microbiota composition of parrots and to link the variation in microbial communities to the incidence of eight selected behavioural and physiological disorders. The gut microbiota composition of 491 individuals from 85 parrot species was analysed using 16S rRNA metabarcoding. The host species, type of feed, and housing environment were identified as the main factors influencing the diversity and composition of the gut microbiota of parrots. A...
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Effects of microbiota composition on emergence of depressions and behavioural disorders in animals
Bartková, Nikola ; Vinkler, Michal (advisor) ; Kubovčiak, Jan (referee)
The aim of this study is to summarize the current knowledge on the influence of gut microbiota composition on behavioural disorders in selected mammals and birds. Current research focuses on the influence of gut microbiota on the development of mental illnesses in humans and the potential therapeutic use of manipulating its composition. This paper briefly summarizes the main mechanisms of microbiota influence on the development of mental illnesses. The gut microbiota may also influence the development of behavioural disorders in animals. The literature suggests that changes in gut microbiota composition in humans with mental illnesses and animals with behavioural disorders share some similarities. In general, they are related mainly to a reduced abundance of selected genera of short-chain fatty acid producing bacteria and an increased abundance of gram-negative bacteria. The exceptions are destructive behavioural disorders in animals, which are associated with increased abundance of the Clostridia class and decreased abundance of the Lactobacillus genus. To prevent their development under stress, the thesis proposes the probiotic use of Lactobacillus rhamnosus. To manipulate the composition of the gut microbiota in the treatment of depressive disorders in humans, the administration of probiotics,...
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The role of gut microbiota and HPA axis in childhood
Trunečková, Naděžda ; Kaňková, Šárka (advisor) ; Kreisinger, Jakub (referee)
The microbiota-host relationship is a complex system of interactions, which has evolved over thousands of years. Colonization of the gastrointestinal tract begins in prenatal period, continues after birth, and can be disrupted by different factors like a mode of delivery, lactation, or antibiotics. Main development of the intestinal microbiota and the central nervous system takes place in the first two or three years of life. The microbiota and the brain can mutually influence their development. For the communication is used the microbiota-gut-brain axis, which includes the neural, endocrine, metabolic and immunological pathways. Exposure to stress, whether in the prenatal period or in the first few years of life, can have a negative impact on the composition of the intestinal microbiota and the developing brain, including areas associated with the regulation of the HPA axis - one of the main mechanisms of stress regulation, which includes all interactions between the hypothalamus, pituitary gland and adrenal glands. Dysregulation of the microbiota-gut-brain axis can affect our response to stress, cognitive function, and emotions. The modified HPA axis response can affect our physical and mental health. It is associated with immune system disorders, behavioural disorders, social integration...
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